Absence of Conduction of Spreading Depression through Cortical Region Damaged by Asphyxiation.

HULL, C. D., AND A. VAN HARREVELD. Absence oj conduction of spreading de)wession through cortical region damaged by asphyxiation. Am. J. Physiol. 207(4) : 92 I-924. Ig6+-An area of cerebral cortex was asphyxiated for 30-35 min by application of a weight exerting a pressure on the tissue greater than the blood pressure. Three days later the asphyxiated region showed in most. experiments a marked loss of nerve cells. The glia seemed to be better preserved. Spreading depression could not be made to pass through the area when asphyxiation had caused substantial neuronal destruction. These observations do not support a possible involvement of the glia in the propagation of spreading depression.